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     Generic Alternative Information (updated 11/15/2010)

    The following therapeutic categories contain generic alternatives:

     
    Therapeutic Category Brand Name Generic Name Starting Dose Usual Dosage
     (if applicable)  (or range)
    ANTIDIABETIC AGENTS (ORAL):
    Biguanide Glucophage/XR  metformin IR:500mg bid IR:up to 1000mg bid
    XR:500mg daily XR:up to 1000mg-2000mg daily
    Sulfonylurea Glucotrol/XL glipizide IR: 5 mg daily IR: 5-15mg/day
    XL: 5 mg daily  XL: 5-20mg/day
    Glynase Pres-Tab glyburide 1.5-3mg daily in single or divided doses 1.25-20mg/day as single or divided doses 
    Micronase/DiaBeta glyburide 2.5-5mg daily w/breakfast Or first meal 1.25-20mg/day as single or divided doses 
    Biguanide/Sulfonylurea Glucovance glyburide/metformin 1.25mg/250mg daily-bid w/meals up to 10mg/2000mg per day
    ANTIDEPRESSANTS:
    SSRI Celexa citalopram 20 mg daily 40 mg daily (depression)
    Luvox fluvoxamine 50 mg daily 50-150 mg bid
    Paxil paroxetine 20 mg daily 20- 50 mg daily
    Zoloft sertraline 50 mg daily 50-100 mg daily
     
    α-antagonist Remeron mirtazepine 15 mg nightly 15-45 mg/day
    Effexor venlafaxine 75 mg daily, divided in 2-3 doses 150 - 225 mg/day
    SNRI   venlafaxine ER **NOTE** Not AB rated to Effexor XR. Rx must be written for "venlafaxine ER" 37.5 - 75 mg daily 75 - 225 mg/day
    Dopamine-Reuptake Inhibitor Wellbutrin bupropion IR: 100 mg bid IR: 100 mg tid
    SR: 150 mg qam SR: 150 mg bid
    XL: 150 mg qam XL: 150-300 mg daily
    ANTIHISTAMINES / NASAL STEROIDS:
    Non-sedating Antihistamine Allegra/Allegra-D fexofenadine   60 mg bid or 180 mg daily (allergic rhinitis)
    Claritin OTC loratadine   10 mg daily
    Nasal Steroids  Nasarel flunisolide   2 sprays en bid
    Flonase fluticasone 2 sprays en daily  1 spray en daily
    CARDIOVASCULAR AGENTS:
    ACE-Inhibitors Accupril quinapril 10-20 mg daily 10-40 mg daily (hypertension)
    Capoten captopril 12.5-25 mg bid-tid 25-100 mg in 2 divided doses
    Lotensin benazepril 10 mg daily 20-40 mg daily
    Monopril fosinopril 10 mg daily 20-40 mg daily
    Prinivil/Zestril lisinopril 10 mg daily 10-40 mg daily
    Vasotec enalapril 2.5-5 mg daily 2.5-40 mg daily
    ARB Cozaar losartan 50 mg daily 25-100 mg daily
    Hyzaar losartan/HCTZ 50/12.5 mg daily Max dose of 100/25 mg daily
          Beta Blockers Beta-1 Selective Lopressor metoprolol 50mg bid 50-100mg/day (hypertension)
    Tenormin atenolol 25-50mg daily 25-100mg/day
    Non-Selective Betapace/AF sotalol 80mg bid 160-320mg/day in 2-3 divided doses (ventricular arrhythmias)
    Corgard nadolol 40mg daily 40-120mg/day
    Inderal propranolol 40mg bid 40-160mg/day in 2 divided doses
    w/ISA Activity Sectral acebutolol 400mg daily 200-800mg/day in 2 divided doses
    Beta/Alpha Normodyne/Trandate labetolol 100mg bid 200-800mg/day in 2 divided doses
    Coreg carvedilol 3.125 bud Titrate as tolerated up to 25-50mg bid for heart failure
     Calcium Channel Blockers Dihydropyridine Norvasc amlodipine 5 mg daily 5-10 mg daily
    Adalat CC nifedipine 30mg daily 30-90mg daily (hypertension)
    Plendil felodipine 5mg daily 2.5-20mg/day
    Procardia XL nifedipine 30mg daily 30-60mg daily
    Diphenylalkylamine Calan; Isoptin; Verelan             verapamil IR: 80mg tid IR:80-320mg/day in 2 divided doses; SR: 120-360mg/day in 2 divided doses
    SR: 240 mg daily 
    Benzothiazepine Cardizem CD/SR diltiazem CD: 180-240mg daily CD: 120-420mg/day daily
    SR: 60-120mg bid SR: 240-360mg/day
    Dilacor XR diltiazem XR: 180-240mg daily XR: 180-420mg daily
    Tiazac diltiazem 120-240mg daily 120-540mg daily
    ANTIHYPERLIPIDEMICS:
    Fibric Acid Derivative Lopid gemfibrozil   600mg bid 
    HMG-CoA Reductase Inhibitors Mevacor lovastatin 20mg daily 10-40 mg/day
    Pravachol pravastatin 40mg daily 10-80mg/day
    Zocor simvastatin 20-40mg daily hs 5-80mg/day
    ANTIMICROBIALS:
       
    Antifungals Cytovene ganciclovir   1000 mg TID
    Famvir famciclovir   125mg BID for 5 days (recurrent episodes)
    Valtrex valacyclovir   1000 mg TID for 7 days (zoster); 500 mg BID for 3 days (recurrent genital); 1000 mg once daily (suppressive therapy)
    Zovirax acyclovir   800 mg five times daily for 7-10 days (zoster); 200 mg fives times daily for 10 days (recurrent genital)
    Antivirals Diflucan fluconazole   200mg daily (esophageal candidiasis); 150mg x 1 (vaginal candidiasis)
    Grifulvin griseofulvin   500 - 1000 mg/day (Tinea infections)
    Nizoral ketoconazole   200-400mg daily (candidiasis)
    Sporanox itraconazole   200mg daily (aspergillosis/onychomycosis)
       Cephalosporins 1st Generation Duricef cefadroxil   1-2g in 2 divided doses (bacterial infection)
    Keflex cephalexin   250-1000mg q6h
    2nd Generation Ceclor/CD cefaclor   250-500mg q8h
    Ceftin cefuroxime   250-500mg BID x 10d
    3rd Generation Vantin cefpodoxime   100-400mg q12h x 7-14d
    Macrolides Biaxin/XL clarithromycin   IR: 250-500mg q12h x 7-14d (bacterial infection)
    XL:1000mg q24h x 7-14d
    Ery-Tab erythromycin   250-500mg q6-12h
    Zithromax azithromycin   500mg on day 1, then 250mg/day on days 2-5
    Quinolones Cipro ciprofloxacin   500mg q12h (bacterial infection)
    Floxin ofloxacin   400mg q12h
    ANTI-INFLAMMATORY AGENTS:
    Non-Steroidal Anti-inflammatory agents (NSAIDS) Anaprox/DS, Naprosyn/EC Naproxen   IR: 250-500mg bid (osteoarthritis)
    ER: 750-1000mg once daily
    Ansaid flurbiprofen   200-300mg in 2-4 divided doses
    Cataflam diclofenac   100-150mg/day in 2-3 divided doses
    Clinoril sulindac   150mg BID
    Daypro oxaprozin   600-1200mg once daily
    Dolobid diflunisal   500-750 mg in divided doses
    Feldene piroxicam   10-20mg daily
    Indocin/SR indomethacin   IR: 25-50mg in 2-3 doses (max:200mg/day)
    SR: 75mg daily-bid (max: 150mg/day)
    Lodine/XL Etodolac   IR: 300mg bid-tid
    XL: 400-1000mg daily
    Mobic meloxicam   Osteoarthritis: 7.5 mg once a day, (max 15 mg/day)
    Rheumatoid arthritis: 7.5 mg once a day, (max 15 mg/day)
    Motrin ibuprofen   400mg q4-6 h prn (max: 3200mg/day)
    Nalfon fenoprofen   300mg q6-8 h prn (max: 3200mg.day)
    Orudis ketoprofen   75mg tid (max: 300mg/day)
    Relafen nabumetone   1000mg daily (max: 2000mg/day)
    Tolectin/DS tolmetin   600-1800mg/day (max:2000mg/day)
    Voltaren/XR diclofenac   IR:100-150mg/day in 2-3 divided doses; ER: 100-200mg/day
    MISCELLANEOUS:
    Triptan Agents                                              Imitrex                                    sumatriptan                                                                            One time doses: 25-100mg PO; 5-20mg Nasal; 6mg SC                          
    Bisphosphonates                                          Fosamax                                 alendronate                                                                            70mg weekly
    Proton Pump Inhibitors Prilosec omeprazole   20-40mg daily (GERD)
    Prilosec OTC (generic OTC now available) omeprazole   20mg daily
    Prevacid lansoprazole   15-30mg daily
    Prevacid 24--OTC (15 mg) lansoprazole   15mg daily
    Protonix pantoprazole   20-40mg daily
    References:
    1. Wickersham, RM, editor.  Drug Facts and Comparisons. St. Louis (MO): Facts and Comparisons; 2005.
    2. Lacy, C. Drug Information Handbook, 13th Edition. Lexi-Comp, Inc Hudson (OH); 2005.
    3. MICROMEDEX® Healthcare Series. Thomson Micromedex, Greenwood Village, (CO), [Edition expires 3/31/06].
    These are general doses and dosage ranges, based on published references.  Therapeutic decisions should be made based on individual patient specific conditions.

     


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